NuPET PET/MRI 嵌入式聯(lián)用掃描儀

NuPET™ PET/MRI 嵌入式聯(lián)用掃描儀

產(chǎn)品概述:

用于PET/MR成像的革命性的磁共振兼容PET掃描儀，允許同時(shí)測(cè)量體內(nèi)的分子和功能過程，Cubresa的 NuPET™是一個(gè)革命性的 PET掃描儀，可插入到現(xiàn)有的MRI中，創(chuàng)建一個(gè)功能強(qiáng)大且靈活的混合臨床前體內(nèi)成像平臺(tái) ,將PET的分子靈敏度與MRI的優(yōu)異解剖，結(jié)構(gòu)和功能信息相結(jié)合。使用同步PET/MRI成像的研究人員可以同時(shí)測(cè)量多種生理過程，同時(shí)具有出色的組織對(duì)比度，定量準(zhǔn)確度和研究通量。連續(xù)的PET/MRI掃描可以在不同的時(shí)間獲取數(shù)據(jù)，當(dāng)動(dòng)物生理學(xué)在幾分鐘內(nèi)發(fā)生變化時(shí)，難以分析重要的功能關(guān)系。通過NuPET的同步掃描，PET和MRI協(xié)同工作，捕捉以前無法達(dá)到的時(shí)間同步和高度互補(bǔ)的信息 - 這樣您就可以開辟新的發(fā)現(xiàn)之路。

NuPET™ 技術(shù)特點(diǎn)：

√ 在你的MRI中同時(shí)進(jìn)行全身小鼠和鼠腦成像

√ 支持廣泛的MRI系統(tǒng)，包括高場(chǎng)模型，以及小動(dòng)物梯度的使用

√ 可用的獨(dú)立PET操作系統(tǒng)

√ 全自動(dòng)的 PET/MRI 圖像配準(zhǔn)

√ 行業(yè)內(nèi)最小尺寸

特別精確的PET / MR圖像配準(zhǔn)和配對(duì)的PET和MRI數(shù)據(jù)點(diǎn)引發(fā)了諸如基于MR的運(yùn)動(dòng)校正和部分容積校正（PVC）等增加PET定量準(zhǔn)確性的進(jìn)展。利用MRI的高軟組織對(duì)比度，可以使用解剖數(shù)據(jù)準(zhǔn)確繪制VOI，而無需猜測(cè)。較短的麻醉持續(xù)時(shí)間有助于減少動(dòng)物的壓力，并降低誘發(fā)可能影響研究質(zhì)量的生理變化的風(fēng)險(xiǎn)。

技術(shù)原理：

對(duì)于生物的安裝，Cubresa做了一個(gè)更大的套筒，適合于PET的插入。這個(gè)套筒有一個(gè)可充氣的橡皮管，可以被抽上來。這個(gè)大套筒適合于核磁共振孔徑的2或3毫米之內(nèi)，然后使橡膠套筒被泵起以保持PET插入到位和減輕振動(dòng)效果。該系統(tǒng)的工作流程包括用于從前端出口的核磁共振線圈的調(diào)諧棒。這使得動(dòng)物，動(dòng)物的處理，動(dòng)物的定位和調(diào)優(yōu)都可以從MRI的前部，節(jié)省時(shí)間和麻煩。對(duì)于這種MRI機(jī)械的安排，一個(gè)支持和鎖條被設(shè)計(jì)成允許適合于一些定制的硬件孔槽。

應(yīng)用領(lǐng)域：

神經(jīng)科學(xué)—受體活性，功能藥理學(xué)

腫瘤學(xué)—腫瘤特征及治療反應(yīng)評(píng)估

心臟病學(xué)—多參數(shù)功能和代謝評(píng)估

探針發(fā)展—“聰明”造影劑􀀁

應(yīng)用案例

加拿大倫敦勞森研究

Cubresa在加拿大安大略省倫敦勞森研究所安裝了NuPET系統(tǒng)用于臨床前研究。該系統(tǒng)用于3T西門子生物圖。Cubresa提供機(jī)械附件，西門子床可與PET插入一起使用。這個(gè)系統(tǒng)的工作流程很重要。?？空疚挥谕獾姆块g由于病人安全問題,因此電纜來自濾板的板,通過核磁共振成像系統(tǒng),并延伸到前面的MRI寵物準(zhǔn)備插入和動(dòng)物運(yùn)動(dòng)系統(tǒng),如上圖所示。

亞利桑那大學(xué)

亞利桑那大學(xué)有一個(gè)7T布魯克爾系統(tǒng)和20厘米的孔。這些系統(tǒng)通常使用BGS- 12A漸變，內(nèi)徑為116毫米。Cubresa NuPET設(shè)計(jì)用于MRI，因此不需要外部套管。這個(gè)系統(tǒng)的工作流程從后面插入一個(gè)NuPET，從前面插入一個(gè)床系統(tǒng)。

NuPET™ 技術(shù)參數(shù)：

文獻(xiàn)列表：

[1] Dr. Gregory Stortz (2016), “Development of a small animal MR compatible PET insert” (Doctoral Thesis). Department of Physics and Astronomy, University of British Columbia.

[2] Graham Schellenberg (2015), “An algorithm for automatic crystal identification in pixelated scintillation detectors using thin plate splines and Gaussian mixture models” (Master's Thesis). Department of Physics and Astronomy, University of Manitoba.

[3] Ehsan Shams (2014), “A slow control system with gain stabilization for a small animal MR –compatible PET insert” (Master's Thesis). Graduate Program in Biomedical Engineering, University of Manitoba.

[4] Chen-Yi Liu (2013), “Characterization of silicon photomultiplier readout designs for us in positron emission tomography systems” (Master's Thesis). Department of Physics & Astronomy, University of Manitoba.

[5] Leonid Lamwertz (2013), “Data acquisition and real-time signal processing in positron emission tomography” (Master's Thesis). Department of Electrical & Computer Engineering, University of Manitoba.

[6] Dr. Fazal ur-Rehman (2012), “Design and development of detector modules for a highly compact and portable preclinical PET system”, (DoctoralThesis). Department of Physics & Astronomy, University of Manitoba.

[7] C. J. Thompson et al., “Comparison of single and dual layer scintillator blocks for preclinical MRI-PET” IEEE Transactions on Nuclear Science, 2012

[8] X. Zhang et al., “Development and evaluation of a LOR-based image reconstruction with 3D system response modeling for a PET insert with dual-layer offset crystal design”, Physics in Medicine and Biology, 2013 Dec 7;58(23):8379-99.

[9] "Measurement of energy and timing resolution of very highly pixellated LYSO crystal blocks with multiplexed SiPMreadout for use in a small animal PET/MR insert", Christopher J. Thompson, Andrew L Goertzen, Poitr Kozlowski, Fabrice Retiere, Greg Stortz, Vesna Sossi, Xuezhu Zhang, Nuclear Science Symposium and Medical Imaging Conference (NSS/MIC) 2013 IEEE, pp. 1-5, 2013.

[10] “Design and Performance of a resistor multiplexing readout circuit for a SiPMdetector array” Andrew L Goertzen, Xuezhu Zhang, Megan M McClarty, Eric J Berg, Chen-Yi Liu, Piotr Kozlowski, Fabrice Retière, Lawrence Ryner, Vesna Sossi, Greg Stortz, Christopher J Thompson, 2013/6, J. IEEE Trans. Nuc. Sci

[11] G. Stortz, M. D. Walker, C. J. Thompson, A. L. Goertzen, F. Retière, X. Zhang, J. D. Thiessen, P. Kozlowski, and V. Sossi, "Characterization of a New MR Compatible Small Animal PET Scanner Using Monte-Carlo Simulations," IEEE Trans. Nucl. Sci., vol. 60, no. 3, pp. 1637-1644, Jun. 2013.

[12] “A PET detector interface board and slow control system based on the Raspberry Pi®”, E. Shams et al, Nuc. Sci Symposium and Med Imaging Conference, 2013 IEEE

[13] Thiessen, J.D., Jackson, C., O’Neill, K., Bishop, D., Kozlowski, P., Retière, F., Sossi, V., Stortz, G., Thompson, C.J., & A.L. Goertzen. Performance Evaluation of SensL SiPMArrays for High-Resolution PET. 2013 IEEE Nuclear Science Symposium and Medical Imaging Conference Seoul, Korea, October

27, 2013.

[14] Zhang, X., Thompson, C.J., Thiessen, J.D., & A.L. Goertzen. “Simulations Studies of a Phoswich PET Detector Design with a Two-Fold Improvement in Spatial Sampling” 2013 IEEE Nuclear Science Symposium and Medical Imaging Conference Seoul, Korea, October 27, 2013.

[15] Thiessen, J.D., Berg, E., Liu, C.-Y., Bishop, D., Kozlowski, P., Retière, F., Sossi, V., Stortz, G., Thompson, C.J., Zhang, X., & A.L. Goertzen. MRCompatibility of a SiPM-Based PET Detector Module Using HDMI for Analog Readout and Power Supply. ISMRM 21st Annual Meeting and Exhibition

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